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28. Januar 2019 (GALENUS)
Self-assembled peptide–poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis
Nature Nanotechnology, volume 14, pages 287–297 (2019)
Shan Guan, Antje Munder, Silke Hedtfeld, Peter Braubach, Silke Glage, Longgui Zhang, Stefan Lienenklaus, Anja Schultze, Günther Hasenpusch, Wiebke Garrels, Frauke Stanke, Csaba Miskey, Sarah M. Johler, Yadhu Kumar, Burkhard Tümmler, Carsten Rudolph, Zoltan Ivics & Joseph Rosenecker
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1. August 2016 (GALENUS)
Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model
PLoS ONE 11(8), 2016 Aug 15
Christien Bednarski, Katja Tomczak, Beate vom Hövel, Wolf-Michael Weber, Toni Cathomen
Details
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15. November 2012 (GALENUS)
Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer.
Muenthaisong S, Ujhelly O, Polgar Z, Varga E, Ivics Z, Pirity MK, Dinnyes A.
Exp Cell Res. 2012 Nov 15;318(19):2482-9. doi: 10.1016/j.yexcr.2012.07.014. Epub 2012 Jul
28. PubMed PMID: 22846649.
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2. November 2012 (GALENUS)
Derivation and Characterization of Sleeping Beauty Transposon-Mediated Porcine Induced Pluripotent Stem Cells
Kues WA, Herrmann D, Barg-Kues B, Haridoss S, Nowak-Imialek M, Buchholz T,
Streeck M, Grebe A, Grabundzija I, Merkert S, Martin U, Hall VJ, Rasmussen MA,
Ivics Z, Hyttel P, Niemann H. Stem Cells Dev. 2012
Nov 2. [Epub ahead of print] PubMed PMID: 22989381.
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1. November 2012 (GALENUS)
Coupling of epithelial Na+ and Cl- channels by direct and indirect activation by serine proteases.
Gondzik V, Weber WM, Awayda MS. Am J Physiol Cell Physiol.
2012 Nov;303(9):C936-46. doi: 10.1152/ajpcell.00395.2011. Epub 2012 Aug 22.
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16. Oktober 2012 (GALENUS)
Lentiviral shRNA delivery reduces apical sodium channel activity in differentiated human airway epithelial cells.
Aarbiou J, Copreni E, Buijs-Offerman RM, van der Wegen P, Castellani S,
Carbone A, Tilesi F, Fradiani P, Hiemstra PS, Yueksekdag G, Diana A, Rosenecker
J, Ascenzioni F, Conese M, Scholte BJ
J Gene Med. 2012 Oct 16. doi: 10.1002/jgm.2672. [Epub ahead of print] PubMed PMID:
23074129.
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16. Oktober 2012 (GALENUS)
Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.
Hozumi A, Mita K, Miskey C, Mates L, Izsvak Z, Ivics Z, Satake H, Sasakura Y.
Dev Dyn. 2012 Oct 16. doi: 10.1002/dvdy.23891. [Epub ahead of print] PubMed PMID: 23073965.
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16. Oktober 2012 (GALENUS)
The non-toxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease mediated gene targeting
Rahman SH, Bobis-Wozowicz S, Chatterjee D, Gellhaus K, Pars K, Heilbronn R,
Jacobs R, Cathomen T. Hum Gene Ther. 2012 Oct 16. [Epub ahead of print] PubMed PMID:
23072634.
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1. Oktober 2012 (GALENUS)
Retargeting Sleeping Beauty Transposon Insertions by Engineered Zinc Finger DNA-binding Domains.
Voigt K, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z.
Mol Ther. 2012 Oct;20(10):1852-62. doi: 10.1038/mt.2012.126.
Epub 2012 Jul 10. PubMed PMID: 22776959; PubMed Central PMCID: PMC3464645.
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1. Oktober 2012 (GALENUS)
TALE nucleases: tailored genome engineering made easy.
Mussolino C, Cathomen T. Curr Opin Biotechnol. 2012 Oct;23(5):644-50. doi:
10.1016/j.copbio.2012.01.013. Epub 2012 Feb 17. PubMed PMID: 22342754.
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1. August 2012 (GALENUS)
Retargeting transposon insertions by the adeno-associated virus Rep protein.
Ammar I, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z.
Nucleic Acids Res. 2012 Aug;40(14):6693-712. doi: 10.1093/nar/gks317. Epub 2012
Apr 19. PubMed PMID: 22523082; PubMed Central PMCID: PMC3413126.
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23. Juli 2012 (GALENUS)
MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration
Yuan Q, Loya K, Rani B, Möbus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A,
Manns MP, Ott M, Cantz T, Sharma AD. Hepatology. 2012 Jul 23. doi:
10.1002/hep.25984. [Epub ahead of print] PubMed PMID: 22821679.
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10. Juli 2012 (GALENUS)
Retargeting Sleeping Beauty Transposon Insertions by Engineered Zinc Finger
Voigt K, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z.
Mol Ther. 2012 Oct;20(10):1852-62. doi: 10.1038/mt.2012.126. Epub 2012 Jul 10. PubMed PMID: 22776959; PubMed Central PMCID: PMC3464645.
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1. Juli 2012 (GALENUS)
Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.
Petrakis S, Raskó T, Mátés L, Ivics Z, Izsvák Z, Kouzi-Koliakou K, Koliakos G.
Biotechnol J. 2012 Jul;7(7):891-7. doi:10.1002/biot.201100471. Epub 2012 Mar 7. PubMed PMID: 22323455.
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1. Juli 2012 (GALENUS)
Precision genetic engineering in large mammals.
Garrels W, Ivics Z, Kues WA. Trends Biotechnol. 2012 Jul;30(7):386-93. Epub 2012 Apr 20. Review. PubMed PMID: 22521716.
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1. Juli 2012 (GALENUS)
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
Cathomen T, Scharenberg AM, Joung JK. Nucleic Acids Res. 2012
Jul;40(12):5560-8. Epub 2012 Feb 28. PubMed PMID: 22373919; PubMed Central PMCID:
PMC3384306.
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1. Juni 2012 (GALENUS)
Highly efficient zinc-finger nuclease-mediated disruption of an eGFP transgene in keratinocyte stem cells without impairment of stem cell properties
Höher T, Wallace L, Khan K, Cathomen T, Reichelt J. Stem Cell Rev. 2012
Jun;8(2):426-34. PubMed PMID: 21874280.
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1. Mai 2012 (GALENUS)
Magnetized aerosols comprising superparamagnetic iron oxide nanoparticles improve targeted drug and gene delivery to the lung.
Hasenpusch G, Geiger J, Wagner K, Mykhaylyk O, Wiekhorst F, Trahms L,
Heidsieck A, Gleich B, Bergemann C, Aneja MK, Rudolph C.
Pharm Res. 2012 May;29(5):1308-18. Epub 2012 Jan 21.PubMed PMID: 22271050.
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19. April 2012 (GALENUS)
Retargeting transposon insertions by the adeno-associated virus Rep protein.
Ammar I, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z.
Nucleic Acids Res. 2012 Aug;40(14):6693-712. doi: 10.1093/nar/gks317. Epub 2012
Apr 19. PubMed PMID: 22523082; PubMed Central PMCID: PMC3413126.
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1. März 2012 (GALENUS)
Formation of solid lipid nanoparticle (SLN)-gene vector complexes for transfection of mammalian cells in vitro.
Rudolph C, Rosenecker J. Cold Spring Harb Protoc. 2012 Mar 1;2012(3):357-60. doi: 10.1101/pdb.prot068122. PubMed PMID:22383641.
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1. März 2012 (GALENUS)
Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors
Händel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, Müller-Lerch F, Kotin
RM, Heilbronn R, Cathomen T. Hum Gene Ther. 2012 Mar;23(3):321-9. Epub 2011 Dec 14. PubMed PMID: 21980922; PubMed
Central PMCID: PMC3300077.
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1. März 2012 (GALENUS)
A novel zinc-finger nuclease platform with a sequence-specific cleavage module.
Schierling B, Dannemann N, Gabsalilow L, Wende W, Cathomen T, Pingoud A.
Nucleic Acids Res. 2012 Mar;40(6):2623-38. Epub 2011 Dec 1. PubMed PMID:
22135304; PubMed Central PMCID: PMC3315325.
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1. März 2012 (GALENUS)
DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8
Alex M, Weger S, Mietzsch M, Slanina H, Cathomen T, Heilbronn R.J Virol. 2012
Mar;86(5):2859-63. Epub 2011 Dec 28. PubMed PMID: 22205745; PubMed Central PMCID:
PMC3302247.
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1. Februar 2012 (GALENUS)
The Sleeping Beauty transposon system for clinical applications.
Swierczek M, Izsvák Z, Ivics Z. Expert Opin Biol Ther. 2012 Feb;12(2):139-53. Epub 2011
Dec 19. Review. PubMed PMID: 22176302.
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1. Januar 2012 (GALENUS)
Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery
Matschke J, Bohla A, Maucksch C, Mittal R, Rudolph C, Rosenecker J.
PLoS One. 2012;7(2):e24615.
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1. Januar 2012 (GALENUS)
The Sleeping Beauty transposon toolbox.
Ammar I, Izsvák Z, Ivics Z. Methods Mol Biol. 2012;859:229-40. Review. PubMed PMID: 22367875.
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1. Januar 2012 (GALENUS)
Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines
Dreyer AK, Cathomen T. Methods Mol Biol. 2012;813:145-56. PubMed
PMID: 22083740.
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14. Dezember 2011 (GALENUS)
Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.
Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lütge F, Glage S, Rudolph
C, Cantz T, Schwarz K, Heilbronn R, Cathomen T.
PLoSOne. 2011;6(12):e28911. Epub 2011 Dec 14. PubMed PMID: 22194948; PubMed Central
PMCID: PMC3237556.
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30. August 2011 (GALENUS)
On target? Tracing zinc-finger-nuclease specificity.
Mussolino C, Cathomen T. Nat Methods. 2011 Aug 30;8(9):725-6. doi: 10.1038/nmeth.1680. PubMed PMID:21878917.