Research for Rare - Research for rare diseases

mitoNET – German Network for Mitochondrial Diseases

Mitochondrial diseases are a heterogeneous group of diseases characterized by mitochondrial dysfunction. The main function of mitochondria is the energy supply to the cell. They also play an important role in intermediate metabolism, apoptosis and the formation of reactive oxygen species. In principle, mitochondrial disease can affect any organ at any age and with any degree of severity, so that there are thousands of possible symptom constellations. Tissues with high energy demand, such as the brain, sensory organs, extraocular and skeletal muscles, heart, liver, kidneys or the endocrine gland, are most often affected. Despite diagnostic progress and the clarification of molecular mechanisms, there is still no cure for mitochondrial diseases. mitoNET with its already established horizontal clinical expert network, the clinical patient registry, the biobank and all its scientific subprojects will primarily benefit the affected patients, enabling a quicker and direct classification of their symptoms through improved diagnostics as well as the development of new therapy methods in the longer term.

Prof. Dr. med. Thomas Klopstock
Klinikum der Universität München
an der Neurologischen Klinik und Poliklinik
Ziemssenstr. 1a
80336 München

Tel.: +49 (0)89 4400 57400
Coordinating office:
Dr. Boriana Büchner
Tel: +49 (0)89 4400 57421