Translational Research for Persons with Abnormal DNA Damage Response
Disorders with Abnormal DNA Damage Response (DADDR) are rare genetic conditions with impaired DNA repair or maintenance. A shared feature among affected individuals is a strongly increased cancer risk. Treatment is commonly complicated due to the underlying genetic defect. Patients may suffer from excessive toxicity/secondary neoplasms, poor treatment response, and high mortality when treated with standard radiation/chemotherapy regimens. The development of treatment strategies is urgently needed. The proposed consortium is composed of patient representatives, physicians from the areas of psychosomatic medicine, gynecology, pediatric and adult hematology/oncology, radiology, pathology, and human genetics, and scientists specialized in cancer and DNA repair.
We aim at improving patient information/involvement as well as therapeutic guidance for health professionals; further elucidating disease-causing mechanisms; improving both psycho-social support and cancer surveillance employing innovative magnetic resonance imaging techniques in patients with Li-Fraumeni syndrome; advancing the use of brush biopsies employed as cancer surveillance tool for individuals with Fanconi anemia who exhibit an excessive oral cancer risk; identifying genetic markers of leukemia development; characterizing the genetic and epigenetic profiles of tumors to exploit these findings diagnostically and identify novel vulnerabilities for treatment and investigate new cancer therapies in pre-clinical disease models.
- Information, Communication, Data, Co-ordination (Prof. Dr. Christian Peter Kratz, Prof. Dr. Lorenz Grigull, Dr. Beate Barbara Doergeloh, Christina Maria Dutzmann, Hannover)
- Gene identification and functional analysis (Dr. Reinhard Kalb, Prof. Dr. Detlef Schindler, Würzburg)
- Optimization of the surveillance program for patients with DADDRs (Prof. Dr. Sarah Schott, Dr. Imad Maatouk, Heidelberg)
- Early Cancer Diagnosis (Dr. Sebastian Bickelhaupt, Prof. Dr. Sarah Schott, Dr. Tristan Kuder, Dr. Katerina Deike-Hofmann, Heidelberg
- Oral cancer surveillance for patients with Fanconi Anemia (Dr. Martin Schramm, Dr. Eunike Velleuer, Ralf Dietrich, Düsseldorf, Mönchengladbach, Dortmund)
- Marker in leukemia-development (2 projects: Prof. Dr. Gudrun Goehring, Dr. Kathrin Thomay, Hannover, and Prof. Dr. Felicitas Thol, Hannover)
- Molecular tumour profiling (Prof. Dr. Stefan M. Pfister, Dr. Natalie Jäger, Dr. Martin Sill, Heidelberg)
- Pre-clinical models (Dr. Till Milde, Heidelberg)
Pediatric Hematology and Oncology
Hannover Medical School
Tel. +49 511 532-6711