1.0Research for Rarehttps://www.research4rare.de/en/mroeselehttps://www.research4rare.de/en/author/mroesele/rich600338<blockquote class="wp-embedded-content" data-secret="G79rUUUbN9"><a href="https://www.research4rare.de/en/alumni/netzwerk-imprinting/">Network for Imprinting Diseases</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.research4rare.de/en/alumni/netzwerk-imprinting/embed/#?secret=G79rUUUbN9" width="600" height="338" title="“Network for Imprinting Diseases” — Research for Rare" data-secret="G79rUUUbN9" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://www.research4rare.de/wp-includes/js/wp-embed.min.js </script> https://www.research4rare.de/wp-content/uploads/2012/12/Netzwerk-Imprinting-Erkrankungen.gif435181The project investigates imprinting defects, which are a rare cause of genetic diseases. Genomic imprints are gamete-of-origin specific chromatin marks (DNA methylation and histone modifications), which make the two parental alleles functionally different. Errors in imprint erasure, establishment and maintenance lead to aberrant gene expression and disease. Imprinting defects contribute to several recognizable syndromes and […]