1.0Research for Rarehttps://www.research4rare.de/en/Katja.Franke-Rupphttps://www.research4rare.de/en/author/katja-franke-rupp/rich600338<blockquote class="wp-embedded-content" data-secret="Kb00VJpwwQ"><a href="https://www.research4rare.de/en/research_networks/hichol/">HiChol</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.research4rare.de/en/research_networks/hichol/embed/#?secret=Kb00VJpwwQ" width="600" height="338" title="“HiChol” — Research for Rare" data-secret="Kb00VJpwwQ" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://www.research4rare.de/wp-includes/js/wp-embed.min.js </script> https://www.research4rare.de/wp-content/uploads/2019/03/hichol_logo_small2.png297174Defective bile handling is referred to as cholestasis and can be caused by mutations in several genes important for bile formation or transport in the liver. Cholestasis as result of genetic variants is referred to as hereditary intrahepatic cholestasis and comprises a heterogeneous group of rare disorders characterized by progressive liver disease often necessitating liver […]