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15. February 2016 (EB-Network)
Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Cancer Res. 2016 Feb 15;76(4):940-51. doi: 10.1158/0008-5472.CAN-15-1348.
Mittapalli VR, Madl J, Löffek S, Kiristi D, Kern JS, Römer W, Nyström A, Bruckner-Tuderman L.
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7. September 2015 (EB-Network)
Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms
EMBO Mol Med. 2015 Sep;7(9):1211-28. doi: 10.15252/emmm.201505061.
Nyström A, Thriene K, Mittapalli V, Kern JS, KIristi D, Dengjel J, Bruckner-Tuderman L.
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23. August 2015 (EB-Network)
High Local Concentrations of Intradermal MSCs Restore Skin Integrity and Faciliate Wound Healing in Dystrophic Epidermolysis Bullosa.
Mol Ther. 2015 Aug;23(8):1368-1379. doi: 10.1038/mt.2015.58.
Kühl T, Mezger M, Hausser I, Handgretinger R, Bruckner-Tuderman L, Nyström A.
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30. March 2014 (EB-Network)
Targeting epidermal lipids for treatment of Mendelian disorders of cornification
Orphanet J Rare Dis. 2014 Mar 7;9:33
Kiritsi D, Schauer F, Wölfle U, Valari M, Bruckner-Tuderman L, Has C, Happle R.
Details
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13. March 2014 (EB-Network)
Underrecognition of acral peeling skin syndrome: 59 new cases with 15 novel mutations.
Br J Dermatol. 2014 Mar 13. doi: 10.1111/bjd.12964. [Epub ahead of print].
Szczecinska W, Nesteruk D, Wertheim-Tysarowska K, Greenblatt DT, Baty D, Browne F, Liu L, Ozoemena L, Terron-Kwiatkowski A, McGrath JA, Mellerio JE, Morton J, Woźniak K, Kowalewski C, Has C, Moss C.
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10. March 2014 (EB-Network)
RhoA activation by CNFy restores cell-cell adhesion in kindlin-2 deficient keratinocytes.
J Pathol. 2014 Mar 10. doi: 10.1002/path.4350. [Epub ahead of print]
He Y, Sonnenwald T, Sprenger A, Hansen U, Dengjel J, Bruckner-Tuderman L, Schmidt G, Has C.
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7. March 2014 (EB-Network)
Targeting epidermal lipids for treatment of Mendelian disorders of cornification.
Orphanet J Rare Dis. 2014 Mar 7;9:33. doi: 10.1186/1750-1172-9-33.
Kiritsi D, Schauer F, Wölfle U, Valari M, Bruckner-Tuderman L, Has C, Happle R.
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1. March 2014 (EB-Network)
he missense mutation p.R1303Q in type XVII collagen underlies junctional epidermolysis bullosa resembling Kindler syndrome.
J Invest Dermatol. 2014 Mar;134(3):845-9.
Has C, Kiritsi D, Mellerio JE, Franzke CW, Wedgeworth E, Tantcheva-Poor I, Kernland-Lang K, Itin P, Simpson MA, Dopping-Hepenstal PJ, Fujimoto W, McGrath JA, Bruckner-Tuderman L.
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1. October 2013 (EB-Network)
Novel and recurrent AAGAB mutations: clinical variability and molecular consequences
J Invest Dermatol. 2013 Oct;133(10):2483-6.
Kiritsi D, Chmel N, Arnold AW, Jakob T, Bruckner-Tuderman L, Has C.
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1. September 2013 (EB-Network)
Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization.
Mol Cell Proteomics. 2013 Sep;12(9):2509-21
Sprenger A, Weber S, Zarai M, Engelke R, Nascimento JM, Gretzmeier C, Hilpert M, Boerries M, Has C, Busch H, Bruckner-Tuderman L, Dengjel J.
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24. August 2013 (EB-Network)
Collagen VII plays a dual role in wound healing
J Clin Invest. 2013 Aug 1;123(8):3498-509
Nyström A, Velati D, Mittapalli VR, Fritsch A, Kern JS, Bruckner-Tuderman L.
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1. July 2013 (EB-Network)
Phenotypic spectrum associated with alpha6beta4 integrin mutations
Br J Dermatol. 2013 Jul;169(1):115-24.
Schumann H, Kiritsi D, Pigors M, Hausser I, Kohlhase J, Peters J, Ott H, Hyla-Klekot L, Gacka E, Sieron AL, Valari M, Leena Bruckner-Tuderman L, Has C.
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27. May 2013 (EB-Network)
Keratins control intercellular adhesion involving PKC-α-mediated desmoplakin phosphorylation
J Cell Biol 201, 681-92, 2013
Kröger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM
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23. May 2013 (EB-Network)
Rat model for DDEB: glycine substitution reduces C7 stability and shows gene-dosage effect
PloS One 8, e64243, 2013
Nyström A, Buttgereit J, Bader M, Shmidt T, Özcelik C, Hausser I, Bruckner-Tuderman L, Kern JS.
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16. April 2013 (EB-Network)
Global remodeling of cellular microenvironment due to loss of collagen VII
Mol Syst Biol, Online Publication 16.04.2013, doi: 10.1038/msb.2013.17
Küttner V, Mack C, Rigbolt KTG, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J.
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24. March 2013 (EB-Network)
Molecular heterogeneity of epidermolysis bullosa simplex: contribution of EXPH5 mutations
J Invest Dermatol. 2014 Mar;134(3):842-5.
Pigors M, Schwieger-Briel A, Leppert J, Kiritsi D, Kohlhase J, Bruckner-Tuderman L, Has C.
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29. January 2013 (EB-Network)
Passive transfer of collagen XVII-specific antibodies induces sustained blistering disease in adult mice.
Orphanet J Rare Dis. 2013 Jan 29;8:17.
Chiriac MT, Licarete E, Sas AG, Rados AM, Lupan I, Chiriac AM, Speth H, Pop-Vancia V, Domsa I, Sesarman A, Popescu O, Sitaru C.
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1. January 2013 (EB-Network)
Keratins mediate localization of hemidesmosomes and represses cell motility
J Invest Dermatol 133, 181-90, 2013
Seltmann K, Roth W, Kröger C, Loschke F, Magin TM.
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1. January 2013 (EB-Network)
Epidermolysis bullosa simplex Ogna revisited
J Invest Dermatol 133, 270-3, 2013 (*equal contribution)
Kiritsi D*, Pigors M*, Tantcheva-Poor I, Wessel C, Arin MJ, Kohlhase J, Bruckner-Tuderman L, Has C.
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1. January 2013 (EB-Network)
Novel and recurrent AAGAB mutations in patients with punctate palmoplantar keratoderma.
J Invest Dermatol, 2013; 133: 2483-2486.
Kiritsi D, Chmel N, Arnold AW, Jakob T, Bruckner-Tuderman L, Has C.
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1. January 2013 (EB-Network)
Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks.
Kidney Int 83 (6), 1052-1064, 2013.
Boerries M, Grahammer F, Eiselein S, Buck M, Meyer C, Goedel M, Bechtel W, Zschiedrich S, Pfeifer D, Laloe D, Arrondel C, Goncalves S, Krüger M, Harvey SJ, Busch H, Dengjel J, Huber TB.
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1. January 2013 (EB-Network)
Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy.
INat Commun 4, 2789, 2013.
Abeliovich H, Zarei M, Rigbolt KTG, Youle RJ, Dengjel J.
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1. January 2013 (EB-Network)
Keratins significantly contribute to cell stiffness and impact on invasive behavior.
Proc Natl Acad Sc 110, 18507-18512, 2013.
Seltmann K, Fritsch A, Käs J, Magin TM.
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21. October 2012 (EB-Network)
The ubiquitin-proteasome system regulates desmoplakin transport to desmosomes in an actin-dependent manner
Exp Dermatol 21, 791-3, 2012.
Löffek S, Bruckner-Tuderman L, Magin TM.
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1. October 2012 (EB-Network)
A novel keratin 5 mutation causes severe EBS accompanied by keratoderma and squamous cell carcinoma
Br J Dermatol 167, 929-36, 2012
Schumann H, Roth W, Has C, Volz A, Erfurt-Berge C, Magin TM, Bruckner-Tuderman L.
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1. October 2012 (EB-Network)
TGM5 mutations impact epidermal differentiation in acral peeling skin syndrome
J Invest Dermatol 132, 2422-2429, 2012
Pigors M, Kiritsi D, Schwieger-Briel A, Suarez J, Faletra F, Aho H, Makela L, Kern JS, Bruckner-Tuderman L, Has C.
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1. August 2012 (EB-Network)
Type 1 segmental Galli-Galli disease resulting from a previously unreported keratin 5 mutation
J Invest Dermatol 132, 2100-3, 2012 (*equal contribution)
Arnold AW*, Kiritsi D*, Happle R, Kohlhase J, Hausser I, Bruckner-Tuderman L, Has C, Itin PH.
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4. June 2012 (EB-Network)
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation
J Exp Med 209,1105-19, 2012
Franzke CW, Cobzaru C, Triantafyllopoulou A, Loeffek S,Horiuchi K, Threadgill DW, Kurz T, Bruckner-Tuderman L, Blobel CP.
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25. May 2012 (EB-Network)
The epidermal basement membrane is a composite of separate laminin- and collagen IV-containing networks connected by aggregated perlecan, but not by nidogens
J Biol Chem 287, 18700-9, 2012
Behrens D, Villone D, Koch M, Brunner G, Sorokin L, Robenek H, Bruckner-Tuderman L, Bruckner P, Hansen U.
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1. May 2012 (EB-Network)
Revertant mosaicism in a human skin fragility disorder results from slippedmispairing and mitotic recombination
J Clin Invest 122,1742-1746, 2012
Kiritsi D, He Y, Pasmooij AMG, Onder M, Happle R, Jonkman M, Bruckner-Tuderman L, Has C.
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19. April 2012 (EB-Network)
Integrin a3 mutations with kidney, lung and skin disease
New Engl J Med 366, 1508-1514, 2012 (*, §, equal contribution)
Has C*, Spartà G*, Kiritsi D*, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L§, Laube GF§
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1. April 2012 (EB-Network)
Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes
Am J Pathol. 180, 1581-92, 2012
Qu H, Wen T, Pesch M, Aumailley M.
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1. November 2011 (EB-Network)
Kindler Syndrome: Extension of mutational spectrum and natural history
Hum Mutat 32, 1204-12, 2011
Has C, Castiglia D, del Rio M, Garcia Diez M, Piccinni E, Kiritsi D, Kohlhase J, Itin P, Martin L, Fischer J, Zambruno G, Bruckner-Tuderman L.
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1. September 2011 (EB-Network)
Efficiency of translation termination in humans is highly dependent upon nucleotides in the neighbourhood of a (premature) termination codon
J Med Genet 48, 640-4, 2011
Pacho F, Zambruno G, Calabresi V, Kiritsi D, Schneider H.
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1. August 2011 (EB-Network)
Dynamic interactions of epidermal collagen XVII with the extracellular matrix: laminin 332 as a major binding partner
Am J Pathol 79, 829-37, 2011
Nishie W, Kiritsi D, Nyström A, Hofmann SC, Bruckner-Tuderman L.
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3. July 2011 (EB-Network)
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons
Nat Neurosci 14, 993-1000, 2011
Chiang LY, Poole K, Oliveira BE, Duarte N, Sierra YA, Bruckner-Tuderman L, Koch M, Hu J, Lewin GR.
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1. July 2011 (EB-Network)
Molecular mechanisms of phenotypic variability in junctional epidermolysis bullosa
J Med Genet 48, 450-7, 2011
Kiritsi D, Kern JS, Schumann H, Kohlhase J, Has C, Bruckner-Tuderman L.
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1. May 2011 (EB-Network)
Lack of Plakoglobin Leads to Lethal Congenital Epidermolysis Bullosa
Hum Mol Genet 20, 1811-9, 2011.
Pigors M, Kiritsi D, Krümpelmann S, Wagner N, He Y, Podda M, Kohlhase J, Hausser I, Bruckner-Tuderman L, Has C.
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1. April 2011 (EB-Network)
Induction of phenotype modifying cytokines by FERMT1 mutations
Hum Mutat 32, 397-406, 2011
Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, Kurz T, Bruckner-Tuderman L, Has C.
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1. March 2011 (EB-Network)
Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification
Am J Pathol 178, 975-82, 2011
He Y, Esser P, Heinemann A, Bruckner-Tuderman L, Has C.
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1. January 2011 (EB-Network)
A secreted variant of cartilage oligomeric matrix protein (COMP) carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis
Arthritis Rheum 63,159-167, 2011
Hansen U, Platz N, Becker A, Bruckner P, Paulsson M, Zaucke F.