AID-Net - Network for Autoinflammatory Disorders in Children and Adolescents
Autoinflammatory syndromes in children and adolescents: Genetics, disease mechanisms, diagnostic markers and therapeutic targets
Autoinflammatory diseases (AID) are characterized by recurrent, self-limited episodes of fever and inflammation. Familial Mediterranean Fever (FMF) is caused by mutations in the MEFV gene. Other inherited AID (like cryopyrin associated peridodic syndromes, CAPS) are linked to defects in the NALP-3 inflammasome with uncontrolled processing of Interleukin-1 beta (IL-1ß). Another autoinflammatory disease without clear genetic background identified so far is Systemic onset Juvenile Idiopathic Arthritis (SoJIA).
Even in disorders with known genetic defects, the genotype-phenotype correlation is weak indicating that confounding factors involving immune dysregulation may be present. Especially IL-1, IL-6 and IL-18 as well as phagocyte-specific S100-proteins (S100A8, S100A9 and S100A12) are correlated with disease activity and secondary complications. Beside IL-6 all these molecules are secreted by a so-called alternative pathway. A loss of control of the alternative secretory pathway seems to be involved in release of innate immune factors leading to autoinflammation.
The primary research goal of this consortium is to elucidate the pathophysiology of autoinflammatory syndromes. Scientific projects focusing on secretory pathways and novel effector mechanisms of innate immunity have been combined with translational approaches to identify genetic and serological markers. This will help to stratify patients, monitor disease activity and therapy, or predict disease outcomes. Finally, novel targets for therapeutic approaches may be identified.
Projects- Rolle von proinflammatorischen S100-Proteinen in autoinflammatorischen Syndromen (Prof. J. Roth, Münster)
- Regulation der IL-1ß-Synthese durch inflammatorische Caspasen und neue IkB-Proteine (Prof. K. Schulze-Osthoff, Tübingen)
- Charakterisierung IKKß-defizienter myeloider Progenitorzellen und die Rolle der gestörten NF-kB Aktivierung bei der systemischen juvenilen iodiopathischen Arthritis (Prof. F. Greten, München)
- Rolle von PI(4,5)P2-induzierter Oligomerisierung und Membraninsertion bei der unkonventionellen Sekretion von FGF2. (Prof. Dr. Walter Nickel, Heidelberg)
- Sekretionsweg des immunmodulatorischen Proteins Annexin A1 (Prof. V. Gerke, Münster)
- Ausbau der bereits bestehenden Biomaterialbank zur Sammlung und Analyse von Patienten-Serum (PD H. Wittkowski, Münster)
- Einrichtung einer genetischen Biobank für autoinflammatorische Erkrankungen (Prof. D. Foell, Münster)
- Zentrales Register für das AID-Netzwerk (Dr. E.Lainka, Duisburg-Essen)
Institut für Immunologie
Universität Münster
Röntgenstr. 21
48149 Münster
Tel.: 0251 83-56577
Fax: 0251 83-56549
E-Mail: rothj@uni-muenster.de
Internet: http://www.campus.uni-muenster.de/immunologie_aid-net.html
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22. March 2021 (AID-Net)
Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis – data from the German AID-registryPediatr Rheumatol. 2021 Mar 22. >>PubMed-Link<<
Lainka E, Baehr M, Raszka B, Haas JP, Hugle B, Fischer N, et al.
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14. September 2018 (AID-Net)
S100-proteins in rheumatic diseasesNature Rev. Rheum.14(9):528-541
Austermann, J., Spiekermann, C., Roth, J.
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15. June 2018 (AID-Net)
Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapyCancer Res. 2018 Jun 15;78(12):3220-3232. doi: 10.1158/0008-5472.CAN-17-3415.
Bauer, R., Udonta, F.*, Wroblewski, M., Ben-Batalla, I., Miranda-Santos, I., Taverna, F., Kuhlencord, M., Gensch, V., Päsler, S., Vinckier, S., Brandner, J.M., Pantel, K., Bokemeyer, C., Vogl, T., Roth, J., Carmeliet, P. & Loges, S.
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28. May 2018 (AID-Net)
Potential of the novel PTA score to identify patients with peritonsillar inflammation profiting from medical treatmentDis. Markers, 2018 May 28;2018:2040746
Spiekermann, C., Roth, J., Vogl, T., Stenner, M. & Rudack, C.
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8. May 2018 (AID-Net)
Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and GlucocorticoidsFront Immunol. 2018 May 8;9:893. doi: 10.3389/fimmu.2018.00893. eCollection 2018.
Heming M, Gran S, Jauch SL, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schäfers M, Roth J, Barczyk-Kahlert K.
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23. March 2018 (AID-Net)
Imaging, myeloid precursor immortalization and genome editing for defining mechanisms of leukocyte recruitment in vivoTheranostics. 2018; 8(9): 2407–2423.
Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, van den Bosch M, van Lent P, Spiekermann C1, Hermann S, Vogl T, Schäfers M, Roth J.
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6. February 2018 (AID-Net)
Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design.ChemMedChem. 2018 Feb 6;13(3):241-250.
Axer, A., Hermann, S., Kehr, G., Clases, D., Karst, U., Fischer-Riepe, L., Roth, J., Fobker, M., Schäfers, M., Gilmour, R., Faust, A.
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15. November 2017 (AID-Net)
Alarmin S100A8 Activates Alveolar Epithelial Cells in the Context of Acute Lung Injury in a TLR4-Dependent MannerFront Immunol. 2017 Nov 13;8:1493. doi: 10.3389/fimmu.2017.01493. eCollection 2017.
Chakraborty D, Zenker S, Rossaint J, Hölscher A, Pohlen M, Zarbock A, Roth J, Vogl T.
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10. August 2017 (AID-Net)
The molecular mechanism underlying unconventional secretion of Fibroblast Growth Factor 2 from tumour cells.Biol Cell. 2017 Aug 10. doi: 10.1111/boc.201700036.
Steringer JP, Nickel W.
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15. March 2017 (AID-Net)
Pro-inflammatory cytokine environments can drive IL-17 over-expression by γδT cells in systemic juvenile idiopathic arthritisArthritis Rheumatol. 2017 Mar 15. doi: 10.1002/art.40099. [Epub ahead of print] Kessel C, Lippitz K, Weinhage T, Hinze C, Wittkowski H, Holzinger D, Fall N, Grom AA, Gruen N, Foell D
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8. March 2017 (AID-Net)
CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.J Invest Dermatol. 2017 Mar;137(3):569-575. doi: 10.1016/j.jid.2016.09.031. Epub 2016 Dec 8.
Van Nuffel E, Schmitt A, Afonina IS, Schulze-Osthoff K, Beyaert R, Hailfinger S.
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21. December 2016 (AID-Net)
Correlation of Secretory Activity of Neutrophils With Genotype in Patients With Familial Mediterranean Fever.Arthritis Rheumatol. 2016 Dec;68(12):3010-3022. doi: 10.1002/art.39784.
Gohar F, Orak B, Kallinich T, Jeske M, Lieber M, von Bernuth H, Giese A, Weissbarth-Riedel E, Haas JP, Dressler F, Holzinger D, Lohse P, Neudorf U, Lainka E, Hinze C, Masjosthusmann K, Kessel C, Weinhage T, Foell D, Wittkowski H.
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19. December 2016 (AID-NetMD-Net)
In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shockFASEB J. 2016 Dec 19. pii: fj.201601083R. [Epub ahead of print] Heinemann AS, Pirr S, Fehlhaber B, Mellinger L, Burgmann J, Busse M, Ginzel M, Friesenhagen J, von Köckritz-Blickwede M, Ulas T, von Kaisenberg CS, Roth J, Vogl T, Viemann D.
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1. November 2016 (AID-Net)
The danger from within: alarmins in arthritisNat Rev Rheumatol. 2016 Nov;12(11):669-68
Nefla M, Holzinger D, Berenbaum F, Jacques C. -
1. October 2016 (AID-NetMD-Net)
Serum cell death biomarker mirrors liver cancer regression after transarterial chemoembolisationAliment Pharmacol Ther. 2016; 44(7):747-54
Bock B, Hasdemir D, Wandrer F, Rodt T, Manns MP, Schulze-Osthoff K, Bantel H. -
28. September 2016 (AID-NetMD-Net)
Alarming consequences – autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1Curr Opin Rheumatol. 2016 Sep;28(5):550-9
Holzinger D, Roth J. -
19. September 2016 (AID-Net)
Alarmins firing arthritis: Helpful diagnostic tools and promising therapeutic targetsJoint Bone Spine. 2016 Sep 19. pii: S1297-319X(16)30127-0
Lavric M, Miranda-García MA, Holzinger D, Foell D, Wittkowski H. -
1. September 2016 (AID-Net)
Alarmin consequences – autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1Curr Opin Rheumatol. 2016 Sept; 28(5):550-9
Holzinger D, Roth J. -
10. August 2016 (AID-Net)
Inflammation and cancer: tissue regeneration gone awryCurr Opin Cell Biol. 2016 Aug 10;43:55-61. doi: 10.1016/j.ceb.2016.07.010
Pesic M, Greten FR. -
13. July 2016 (AID-Net)
Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks?Arthritis Res Ther. 2016 Jul 13;18:163
Gohar F, Kessel C, Lavric M, Holzinger D, Foell D. -
5. July 2016 (AID-NetMD-Net)
Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2JBC Papers in Press, July 5, 2016
Giuseppe La Venuta, Sabine Wegehingel, Peter Sehr, Hans-Michael Müller, Eleni Dimou, Julia P. Steringer, Mareike Grotwinkel, Nikolai Hentze, Matthias P. Mayer, David W. Will§, Ulrike Uhrig, Joe D. Lewis, and Walter Nickel -
22. June 2016 (AID-Net)
Secretory Activity of Neutrophils Correlates With Genotype in Familial Mediterranean FeverArthritis Rheumatol. 2016 Jun 22.
Gohar F, Orak B, Kallinich T, Jeske M, Lieber M, von Bernuth H, Giese A, Weissbarth-Riedel E, Haas JP, Dressler F, Holzinger D, Lohse P, Neudorf U, Lainka E, Hinze C, Masjosthusmann K, Kessel C, Weinhage T, Foell D, Wittkowski H. -
21. June 2016 (AID-NetMD-Net)
Nuclear delivery of recombinant OCT4 by chitosan nanoparticles for transgene-free generation of protein-induced pluripotent stem cellsOncotarget. 2016; 7(25):37728-37739
Tammam S, Malak P, Correa D, Rothfuss O, Azzazy HM, Lamprecht A, Schulze-Osthoff K. -
1. June 2016 (AID-NetMD-Net)
Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and BakJ Cell Sci. 2016;129(11):2213-23
Einsele-Scholz S, Malmsheimer S, Bertram K, Stehle D, Johänning J, Manz M, Daniel PT, Gillissen BF, Schulze-Osthoff K, Essmann F. -
19. April 2016 (AID-NetMD-Net)
The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cellsOncotarget. 2016;7(16):21875-86
Ruiz-Magaña MJ, Martínez-Aguilar R, Lucendo E, Campillo-Davo D, Schulze-Osthoff K, Ruiz-Ruiz C. -
18. April 2016 (AID-Net)
The atypical inhibitor of NF-κB, IκBζ, controls macrophage interleukin-10 expressionJ Biol Chem. 2016 Jun 10;291(24):12851-61. Epub 2016 Apr 18.
Hörber S, Hildebrand DG, Lieb WS, Lorscheid S, Hailfinger S, Schulze-Osthoff K, Essmann F.
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1. April 2016 (AID-Net)
The challenge of trial design in paediatric rheumatologyNat Rev Rheumatol. 2016 Apr;12(4):242
Niehues T. -
1. April 2016 (AID-NetMD-Net)
MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan StimulationJ Invest Dermatol. 2016;136(4):788-97
Schmitt A, Grondona P, Maier T, Brändle M, Schönfeld C, Jäger G, Kosnopfel C, Eberle FC, Schittek B, Schulze-Osthoff K, Yazdi AS, Hailfinger S. -
31. March 2016 (AID-Net)
Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndromeJ Allergy Clin Immunol. 2016 Mar 31. pii: S0091-6749(16)00266-9
Noster R, de Koning HD, Maier E, Prelog M, Lainka E, Zielinski CE. -
1. March 2016 (AID-Net)
TRAPS-Syndrom ohne Nachweis einer Mutation im TNFRSF1A-Gen mit gutem Ansprechen auf Anakinraarthritis und Rheuma 2016, 3/16: 187-189
F. Hamsen; C. Müntjes; W. Kampmann; B. Schweiger; U. Neudorf; E. Lainka -
1. March 2016 (AID-NetMD-Net)
Interferon-Mediated Cytokine Induction Determines Sustained Virus Control in Chronic Hepatitis C Virus InfectionJ Infect Dis. 2016; 213(5):746-54.
Wandrer F, Falk CS, John K, Skawran B, Manns MP, Schulze-Osthoff K, Bantel H. -
12. February 2016 (AID-NetMD-Net)
Inflammasome-dependent IL-1β release depends upon membrane permeabilisationCell Death and Differentiation (2016) 23, 1219–1231
F Martín-Sánchez, C Diamond, M Zeitler, AI Gomez, A Baroja-Mazo, J Bagnall, D Spiller, M White, MJD Daniels, A Mortellaro, M Peñalver5, P Paszek, JP Steringer, W Nickel, D Brough, and P Pelegrín, -
1. February 2016 (AID-NetMD-Net)
The paracaspase MALT1 dampens NF-κB signalling by cleaving the LUBAC subunit HOIL-1FEBS J. 2016 Feb;283(3):400-2
Hailfinger S, Schmitt A, Schulze-Osthoff K. -
1. February 2016 (AID-NetMD-Net)
Decrease of Store-Operated Ca2+ Entry and Increase of Na+/Ca2+ Exchange by Pharmacological JAK2 InhibitionCell Physiol Biochem. 2016;38(2):683-95
Yan J, Hosseinzadeh Z, Zhang B, Froeschl M, Schulze-Osthoff K, Stournaras C, Lang F. -
18. January 2016 (AID-NetMD-Net)
Interrogating Substrate Selectivity and Composition of Endogenous Histone Deacetylase Complexes with Chemical ProbesAngew Chem Int Ed Engl. 2016;55(3):1192-5
Dose A, Sindlinger J, Bierlmeier J, Bakirbas A, Schulze-Osthoff K, Einsele-Scholz S, Hartl M, Essmann F, Finkemeier I, Schwarzer D -
15. December 2015 (AID-Net)
No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritisPediatr Rheumatol Online J. 2015 Dec 15;13(1):61
Eberhardt CS, Haas JP, Girschick H, Schwarz T, Morbach H, Rösen-Wolff A, Foell D, Dannecker G, Schepp C, Ganser G, Honke N, Eggermann T, Müller-Berghaus J, Wagner N, Ohl K, Tenbrock K. -
7. December 2015 (AID-Net)
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritisAnn Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517.
Schelbergen, R. F., E. Geven, M. van den Bosch, H. Eriksson, T. Leanderson, T. Vogl, J. Roth, F. van de Loo, M. Koenders, P. M. van der Kraan, W. B. van den Berg, A. Blom, P. van Lent
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1. December 2015 (AID-Net)
Increased serum concentrations of neutrophil-derived protein S100A12 in heterozygous carriers of MEFV mutationsClin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S113-6
Lieber M, Kallinich T, Lohse P, Klotsche J, Holzinger D, Foell D, Wittkowski H. -
1. November 2015 (AID-Net)
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseasesJ Allergy Clin Immunol. 2015 Nov; 136(5): 1337-1345
Holzinger D, Fassl SK, de Jager W, Lohse P, Röhrig UF, Gattorno M, Omenetti A, Chiesa S, Schena F, Austermann J, Vogl T, Kuhns DB, Holland SM, Rodríguez-Gallego C, López-Almaraz R, Arostegui JI, Colino E, Roldan R, Fessatou S, Isidor B, Poignant S, Ito K, Epple HJ, Bernstein JA, Jeng M, Frankovich J, Lionetti G, Church JA, Ong PY, LaPlant M, Abinun M, Skinner R, Bigley V, Sachs UJ, Hinze C, Hoppenreijs E, Ehrchen J, Foell D, Chae JJ, Ombrello A, Aksentijevich I, Sunderkoetter C, Roth J. -
1. November 2015 (AID-Net)
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)–associated inflammatory diseasesNovember 2015Volume 136, Issue 5, Pages 1337–1345
Dirk Holzinger, MD, Selina Kathleen Fassl, MSc, Wilco de Jager, PhD, Peter Lohse, MD, Ute F. Röhrig, PhD, Marco Gattorno, MD, Alessia Omenetti, MD, Sabrina Chiesa, MD, Francesca Schena, PhD, Judith Austermann, PhD, Thomas Vogl, PhD, Douglas B. Kuhns, PhD, Steven M. Holland, MD, Carlos Rodríguez-Gallego, PhD, Ricardo López-Almaraz, MD, Juan I. Arostegui, MD, PhD, Elena Colino, MD, Rosa Roldan, MD, PhD, Smaragdi Fessatou, MD, Bertrand Isidor, MD, Sylvaine Poignant, MD, Koichi Ito, MD, Hans-Joerg Epple, MD, Jonathan A. Bernstein, MD, PhD, Michael Jeng, MD, Jennifer Frankovich, MD, Geraldina Lionetti, MD, Joseph A. Church, MD, Peck Y. Ong, MD, PhD, Mona LaPlant, MD, Mario Abinun, MD, Rod Skinner, MD, Venetia Bigley, MD, Ulrich J. Sachs, MD, PhD, Claas Hinze, MD, Esther Hoppenreijs, MD, Jan Ehrchen, MD, PhD, Dirk Foell, MD, Jae Jin Chae, PhD, Amanda Ombrello, MD, Ivona Aksentijevich, MD, PhD, Cord Sunderkoetter, MD, Johannes Roth, MD
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1. October 2015 (AID-Net)
From bench to bedside and back again: translational research in autoinflammationNat Rev Rheumatol. 2015 Oct;11(10):573-85
Holzinger D, Kessel C, Omenetti A, Gattorno M. -
28. September 2015 (AID-NetMD-Net)
The Startling Properties of Fibroblast Growth Factor 2: How to Exit Mammalian Cells without a Signal Peptide at HandJBC Papers in Press, September 28, 2015
Giuseppe La Venuta, Marcel Zeitler, Julia P. Steringer, Hans-Michael Müller, and Walter Nickel -
22. July 2015 (AID-Net)
The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndromeArthritis Res Ther. 2015 Jul 22;17:187
de Koning HD, Schalkwijk J, Stoffels M, Jongekrijg J, Jacobs JF, Verwiel E, Koenen HJ, Preijers F, Holzinger D, Joosten I, van der Meer JW, Simon A. -
16. June 2015 (AID-NetMD-Net)
HIV-Tat Protein Forms Phosphoinositide-dependent Membrane Pores Implicated in Unconventional Protein SecretionJBC Papers in Press, July 16, 2015
Marcel Zeitler, Julia P. Steringer, Hans-Michael Müller, Matthias P. Mayer, and Walter Nickel -
26. May 2015 (AID-Net)
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseasesJ Allergy Clin Immunol. 2015 May 26. pii: S0091-6749(15)00576-X. doi: 10.1016/j.jaci.2015.04.016. [Epub ahead of print]
Holzinger D1, Fassl SK2, de Jager W3, Lohse P4, Röhrig UF5, Gattorno M6, Omenetti A6, Chiesa S6, Schena F6, Austermann J7, Vogl T7, Kuhns DB8, Holland SM9, Rodríguez-Gallego C10, López-Almaraz R11, Arostegui JI12, Colino E13, Roldan R14, Fessatou S15, Isidor B16, Poignant S17, Ito K18, Epple HJ19, Bernstein JA20, Jeng M20, Frankovich J20, Lionetti G21, Church JA22, Ong PY22, LaPlant M23, Abinun M24, Skinner R25, Bigley V26, Sachs UJ27, Hinze C28, Hoppenreijs E29, Ehrchen J30, Foell D31, Chae JJ32, Ombrello A32, Aksentijevich I32, Sunderkoetter C33, Roth J34.
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26. May 2015 (AID-Net)
Single amino acid charge switch defines clinically distinct PSTPIP1 associated inflammatory diseasesThe Journal of Allergy and Clinical Immunology (2015, in press)
DOI: http://dx.doi.org/10.1016/j.jaci.2015.04.016Holzinger, D., C. Sunderkoetter, W. de Jager, P. Lohse, U. F. Röhrig, M. Gattorno, S. Chiesa, S. K. Fassl, J. Austermann, T. Vogl, S. M. Holland, C. Rodríguez-Gallego, R. López-Almaraz, J. I. Arostegui, E. Colino, S. Fessatou, B. Isidor, S. Poignant, K. Ito, H.-J. Epple, J. A. Bernstein, M. Jeng, G. Lionetti, J. Frankovich, J. A. Church, P. Y. Ong, M. LaPlant, M. Abinun, C. Hinze, E. Hoppenreijs, J. Ehrchen, D. Foell, J. J. Chae, A. Ombrello, J. Brady , I. Aksentijevich, and J. Roth
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1. May 2015 (AID-Net)
TLR4 dependent activation of human phagocytes by the alarmin MRP8J. Immunol. (2015, in press)
Fassl, S. K., J. Austermann, M. Riemenschneider, C. Spiekermann, A. Witten, D. Viemann, M. Stoll, J. Roth, and T. Vogl J.
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20. April 2015 (AID-Net)
Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesionNat Commun. 2015 Apr 20; 6: 6915. Published online 2015 Apr 20. doi: 10.1038/ncomms7915
Monika Pruenster, Angela R. M., Kurz Kyoung-Jin Chung, Xiao Cao-Ehlker, Stephanie Bieber, Claudia F. Nussbaum, Susanne Bierschenk, Tanja K. Eggersmann, Ina Rohwedder, Kristina Heinig, Roland Immler, Markus Moser, Uwe Koedel, Sandra Gran, Rodger P. McEver, Dietmar Vestweber, Admar Verschoor, Tomas Leanderson, Triantafyllos Chavakis, Johannes Roth, Thomas Vogl, and Markus Sperandioa
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3. April 2015 (AID-Net)
Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfacesThe Journal of Biological Chemistry. 2015 Apr;290:8925-37
Müller HM, Steringer JP, Wegehingel S, Bleicken S, Münster M, Dimou E, Unger S, Weidmann G, Andreas H, García-Sáez AJ, Wild K, Sinning I, Nickel W.
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1. March 2015 (AID-Net)
MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritisAnnals of the Rheumatic Diseases. 2015 Mar;74(3):499-505
Choi, I. Y. K., D. M. Gerlag, M. J.Herenius, R. Thurlings, C. A. Wijbrandts, D. Foell, T. Vogl, J. Roth, P. P. Tak, and D. Holzinger
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1. October 2014 (AID-NetMD-Net)
Monocyte-inducted development of Th17 cells and the release of S100 proteins are involved in the pathogenesis of graft-versus-host diseaseJ Immunol. 2014 Oct 1;193(7):3355-65
Reinhardt K, Foell D, Vogl T, Mezger M, Wittkowski H, Fend F, Federmann B, Gille C, Feuchtinger T,
Lang P, Handgretinger R, Andreas Bethge W, Holzer U. -
21. August 2014 (AID-NetMD-Net)
P wave dispersion and QT dispersion in adult Turkish migrants with familial mediterranean fever living in GermanyInt J. Med Sci. 2014 Aug. 21
Giese A, Ornek A, Kurucay M, Kara K, Wittkowski H, Gohar F, Menge BA, Schmidt WE, Zeidler C. -
7. August 2014 (AID-NetMD-Net)
Activated STING in a vascular and pulmonary syndromeN Engl. J Med. 2014 Aug. 7; 371 (6):507-18
Lui Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanches GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B,
Palmer I, DiGeovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St. Hilaire C, Gurprased S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minnite CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R. -
1. June 2014 (AID-Net)
Validation of relapse risk biomarkers for routine use in patients with juvenile idiopathic arthritisArthritis Care and Research. 2014 Jun;66(6):949–55
Rothmund, F., J. Gerss, N. Ruperto, H. J. Däbritz, Wittkowski, M. Frosch, N. Wulffraat, L. R. Wedderburn, D. Holzinger, F. Gohar, B. Vastert, R. Brik, C. J. Deslandre, J. A. Melo-Gomes, C. S. Magalhaes,. R. Barcellona, R. Russo, M. Gattorno, A. Martini, J. Roth, and D. Foell for the Paediatric Rheumatology International Trials Organization (PRINTO).
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1. May 2014 (AID-Net)
MRP8 and MRP14 promote MSU-crystal induced inflammation in goutArthritis & Rheumatology. May 2014;66(5):1327–1339
Holzinger, D., N. Nippe, T. Vogl, K. Marketon, V. Mysore, T. Weinhage, N. Dalbeth, B. Pool,T. Merriman, D. Baeten, A. Ives, N. Bagnoud, N. Busso, D. Foell, C. Gabay, and J. Roth
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1. July 2013 (AID-Net)
Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signalingBiochimica et Biophysica Acta. 2013 Jul;1833(7):1700-1711
Poeter, M., S. Radke, M. Koese, F. Hessner, A. Hegemann, A. Musiol, V. Gerke, T. Grewal, and U. Rescher
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19. June 2013 (AID-Net)
Overexpression of CREMα in T Cells Aggravates Lipopolysaccharide-Induced Acute Lung InjuryJ Immunol. 2013 Jun 19. [Epub ahead of print] PMID: 23785120
Verjans E, Ohl K, Yu Y, Lippe R, Schippers A, Wiener A, Roth J, Wagner N, Uhlig S, Tenbrock K, Martin C.
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18. June 2013 (AID-Net)
IκBζ is a regulator for the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescenceJ Cell Sci. 2013 Jun 18.
PMID: 23781024Alexander E, Hildebrand DG, Kriebs A, Obermayer K, Manz M, Rothfuss O, Essmann F, Schulze-Osthoff K.
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15. June 2013 (AID-Net)
Proinflammatory S100A12 Can Activate Human Monocytes via Toll-like Receptor 4Am J Respir Crit Care Med. 2013 Jun 15;187(12):1324-34. doi: 10.1164/rccm.201209-1602OC.
PMID: 23611140Foell D, Wittkowski H, Kessel C, Lüken A, Weinhage T, Varga G, Vogl T, Wirth T, Viemann D, Björk P, van Zoelen MA, Gohar F, Srikrishna G, Kraft M, Roth J.
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14. June 2013 (AID-Net)
Trp53 Deficiency Protects against Acute Intestinal InflammationJ Immunol. Epub: 2013 Jun 14.
PMID: 23772033Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
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6. June 2013 (AID-Net)
ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer InitiationCell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9.
PMID: 23665120Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ.
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5. June 2013 (AID-Net)
Inducible expression of transgenic human TNFα in adult mice develops psoriatic-like arthritisArthritis Rheum. 2013 Jun 5. doi: 10.1002/art.38026. [Epub ahead of print] PMID: 23740547
Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent P, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V.
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1. June 2013 (AID-Net)
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1beta productionThe Journal of Allergy and Clinical Immunology. 2013 Jun; 131(6):1635-43
Kolly L, Busso N, von Scheven-Gete A, Bagnoud N, Moix I, Holzinger D, Simon G, Ives A, Guarda G, So A, Morris MA, Hofer M.
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1. May 2013 (AID-Net)
IκBζ is a transcriptional key regulator of CCL2/MCP-1J Immunol. 2013 May 1;190(9):4812-20. doi: 10.4049/jimmunol.1300089. Epub 2013 Apr 1.
PMID: 23547114Hildebrand DG, Alexander E, Hörber S, Lehle S, Obermayer K, Münck NA, Rothfuss O, Frick JS, Morimatsu M, Schmitz I, Roth J, Ehrchen JM, Essmann F, Schulze-Osthoff K.
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25. April 2013 (AID-Net)
A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 proteinRheumatology (Oxford). 2013 Apr 25. [Epub ahead of print] PMID: 23620557
Moncrieffe H, Ursu S, Holzinger D, Patrick F, Kassoumeri L, Wade A, Roth J, Wedderburn LR.
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20. February 2013 (AID-Net)
Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagyCell Death Differ. 2013 Feb;20(2):321-32. doi: 10.1038/cdd.2012.129. Epub 2012 Oct 12.
PMID: 23059785Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I.
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9. January 2013 (AID-Net)
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.EMBO J. 2013 Jan 9;32(1):100-11. doi: 10.1038/emboj.2012.309. Epub 2012 Nov 27.
PMID: 23188082Petersen B, Wolf M, Austermann J, van Lent P, Foell D, Ahlmann M, Kupas V, Loser K, Sorg C, Roth J, Vogl T.
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29. December 2012 (AID-Net)
Quality of life in adult patients with Familial Mediterranean fever living in Germany or Turkey compared to healthy subjects: a study evaluating the effect of disease severity and country of residenceRheumatol Int. 2012 Dec 29.
PMID: 23274441Giese A, Kurucay M, Kilic L, Ornek A, Sendur SN, Lainka E, Henning BF.
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15. December 2012 (AID-Net)
Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearanceJ Immunol. 2012 Dec 15;189(12):5722-8. doi: 10.4049/jimmunol.1200922. Epub 2012 Nov 12.
PMID: 23150713Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K.
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1. December 2012 (AID-Net)
Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative studyAnn Rheum Dis. 2012 Dec;71(12):1991-1997. Epub 2012 Jun 11.
PubMed PMID:22689317.Gerss J, Roth J, Holzinger D, Ruperto N, Wittkowski H, Frosch M, Wulffraat N, Wedderburn L, Stanevicha V, Mihaylova D, Harjacek M, Len C, Toppino C, Masi M, Minden K, Saurenmann T, Uziel Y, Vesely R, Apaz MT, Kuester RM, Elorduy MJ, Burgos-Vargas R, Ioseliani M, Magni-Manzoni S, Unsal E, Anton J, Balogh Z, Hagelberg S, Mazur-Zielinska H, Tauber T, Martini A, Foell D;
for the Paediatric Rheumatology International Trials Organization (PRINTO). -
1. December 2012 (AID-Net)
Release of lysophospholipid ‘find-me’ signals during apoptosis requires the ATP-binding cassette transporter A1Autoimmunity. 2012 Dec;45(8):568-73. doi: 10.3109/08916934.2012.719947. Epub 2012 Sep 17.
PMID: 22913458Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K.
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29. November 2012 (AID-Net)
IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.Immunity. 2012 Dec 14;37(6):998-1008. doi: 10.1016/j.immuni.2012.08.023. Epub 2012 Nov 29.
PMID: 23200824Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kühl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I.
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15. November 2012 (AID-Net)
Diversity in unconventional protein secretionJournal of Cell Science. 2012 Nov;125:5251-55
Rabouille C., V. Malhotra, W. Nickel.
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1. November 2012 (AID-Net)
Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatoryJ Leukoc Biol. 2012
Nov;92(5):1069-81. doi: 10.1189/jlb.0112014. Epub 2012 Aug 14. PubMed PMID:22892107; PubMed Central PMCID: PMC3476237.Holzinger D, Gieldon L, Mysore V, Nippe N, Taxman DJ, Duncan JA, Broglie PM, Marketon K, Austermann J, Vogl T, Foell D, Niemann S, Peters G, Roth J, Löffler B.
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1. October 2012 (AID-Net)
Incidence and clinical features of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) and spectrum of mevalonate kinase (MVK) mutations in German childrenRheumatol Int. 2012 Oct;32(10):3253-60.
Epub 2011 Oct 30.
PubMed PMID: 22038276.Lainka E, Neudorf U, Lohse P, Timmann C, Bielak M, Stojanov S, Huss K, von Kries R, Niehues T.
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19. August 2012 (AID-Net)
Familial Mediterranean fever in Germany: epidemiological, clinical, and genetic characteristics of a pediatric populationEur J Pediatr. 2012 Aug 19. [Epub ahead of print] PubMed PMID: 22903357
Lainka E, Bielak M, Lohse P, Timmann C, Stojanov S, von Kries R, Niehues T, Neudorf U.
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10. August 2012 (AID-Net)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretionJ Biol Chem. 2012 Aug 10;287(33):27659-69. doi: 10.1074/jbc.M112.381939.
Epub 2012 Jun 23.
PubMed PMID: 22730382;
PubMed Central PMCID: PMC3431657.Steringer JP, Bleicken S, Andreas H, Zacherl S, Laussmann M, Temmerman K, Contreras FX, Bharat TA, Lechner J, Müller HM, Briggs JA, García-Sáez AJ, Nickel W.
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6. July 2012 (AID-Net)
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxinPLoS One. 2012;7(7):e40429. Epub 2012 Jul 6. PubMed PMID: 22792315; PubMed Central PMCID: PMC3391278.
Tcatchoff L, Andersson S, Utskarpen A, Klokk TI, Skånland SS, Pust S, Gerke V,
Sandvig K. -
1. July 2012 (AID-Net)
Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label studyAllergy. 2012 Jul;67(7):943-50. doi: 10.1111/j.1398-9995.2012.02843.x.
Epub 2012 May 15.
PubMed PMID: 22583335.Krause K, Weller K, Stefaniak R, Wittkowski H, Altrichter S, Siebenhaar F, Zuberbier T, Maurer M.
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1. June 2012 (AID-Net)
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritisAnn Rheum Dis. 2012
Jun;71(6):974-80. Epub 2012 Jan 20. PubMed PMID: 22267331.Holzinger D, Frosch M, Kastrup A, Prince FH, Otten MH, Van Suijlekom-Smit LW, ten Cate R, Hoppenreijs EP, Hansmann S, Moncrieffe H, Ursu S, Wedderburn LR, Roth J, Foell D, Wittkowski H.
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1. January 2012 (AID-Net)
Translational research network and patient registry for auto-inflammatory diseasesRheumatology (Oxford). 2011 Jan;50(1):237-42.
PubMed PMID: 21148158.Lainka E, Bielak M, Hilger V, Basu O, Neudorf U, Wittkowski H, Holzinger D, Roth J, Niehues T, Foell D.
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1. December 2011 (AID-Net)
MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromesAnn Rheum Dis. 2011
Dec;70(12):2075-81. Epub 2011 Sep 8. PubMed PMID: 21908452.Wittkowski H, Kuemmerle-Deschner JB, Austermann J, Holzinger D,
Goldbach-Mansky R, Gramlich K, Lohse P, Jung T, Roth J, Benseler SM, Foell D. -
1. November 2011 (AID-Net)
Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinasesGenome Res. 2011 Nov;21(11):1955-68.
Epub 2011 Jul 27.
PubMed PMID: 21795383;
PubMed Central PMCID: PMC3205579.Ritzerfeld J, Remmele S, Wang T, Temmerman K, Brügger B, Wegehingel S, Tournaviti S, Strating JR, Wieland FT, Neumann B, Ellenberg J, Lawerenz C, Hesser J, Erfle H, Pepperkok R, Nickel W.
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24. October 2011 (AID-Net)
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cellsJ Exp Med. 2011 Oct 24;208(11):2291-303.
Epub 2011 Oct 10. PubMed PMID: 21987655;
PubMed Central PMCID: PMC3201195.Ghoreschi K, Brück J, Kellerer C, Deng C, Peng H, Rothfuss O, Hussain RZ, Gocke AR, Respa A, Glocova I, Valtcheva N, Alexander E, Feil S, Feil R, Schulze-Osthoff K, Rupec RA, Lovett-Racke AE, Dringen R, Racke MK, Röcken M.
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12. October 2011 (AID-Net)
Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagyCell Death Differ. 2012 Oct 12
doi: 10.1038/cdd.2012.129. [Epub ahead of print] PubMed PMID: 23059785Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I.
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1. October 2011 (AID-Net)
Necrotizing sarcoid granulomatosis: ocular manifestation in 3 children of African originArch Ophtalmol. 2011 Oct;129 (10):1370-2.
PubMed PMID: 21987683Schumacher C, Lohr A, Kaup M, Walter P, Roth J, Perez-Bouza A, Wagner N, heiligenhaus A.
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1. September 2011 (AID-Net)
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitorsExpert Opin Investig Drugs. 2011 Sep;20(9):1263-75.
Epub 2011 Jul 14. Review.
PubMed PMID: 21751940Mankan AK, Greten FR.
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19. April 2011 (AID-Net)
TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosisProc Natl Acad Sci U S A. 2011 Apr 19;108(16):6567-72.
Epub 2011 Apr 4.
PubMed PMID: 21464320;
PubMed Central PMCID: PMC3080999.Mankan AK, Canli O, Schwitalla S, Ziegler P, Tschopp J, Korn T, Greten FR.
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24. March 2011 (AID-Net)
The unconventional secretory machinery of fibroblast growth factor 2. TrafficNickel W.
2011 Jul; 12(7):799-805. doi:10.1111/j.1600-0854.2011.01187.x.
Epub 2011 Mar 24.
PubMed PMID: 21585635 -
15. February 2011 (AID-Net)
Annexin A1 is a new functional linker between actin filaments and phagosomes during phagocytosisJ Cell Sci. 2011 Feb 15;124(Pt 4):578-88.
Epub 2011 Jan 18.
PubMed PMID: 21245195.Patel DM, Ahmad SF, Weiss DG, Gerke V, Kuznetsov SA.
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1. February 2011 (AID-Net)
Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signallingEMBO Mol Med. 2011 Feb;3(2):102-14. doi: 10.1002/emmm.201000113.
Epub 2011 Jan 20. PubMed PMID: 21254404;
PubMed Central PMCID: PMC3377061.Pupjalis D, Goetsch J, Kottas DJ, Gerke V, Rescher U.