TranSaRNet - Translational Sarcoma Research Network
Malignant sarcoma are rare and primarily occur in children, adolescents and young adults. Multimodal therapeutic approaches have significantly raised survival in patients with localized disease up to 60-70%. Following relapse and in patients with primary disseminated disease the prognosis is still unfavorable. Current state of the art therapy often fails to cure the disease in this group of patients. The Translational Sarcoma Research Network (TranSaRNet) aims to improve cure rates in these highrisk sarcoma.
To achieve this goal, novel non-cross-resistant therapies are needed that efficiently target dormant and chemo-resistant residual tumor cells and overcome tumor cell resistance. In addition, the identification of biomedical prognostic factors at the time of diagnosis is a strong focus in the consortium. TranSaRNet is a collaborative network of the German pediatric, adolescent and adult sarcoma research groups with access to over 90% of all pediatric and adolescent sarcoma patients and a large number of adult sarcoma patients.
In the first funding period TranSaRNet facilitated the discovery of putative diagnostic and prognostic markers and new therapeutic targets. Consequently, a number of projects developed in the basic research line are now further developed in the translational research line. The clinical registry complements basic research and data from the registry will further help to identify patients at risk suitable to be included into experimental clinical trials. The virtual biobank will continue to complement basic and translational research. With the chance to use Next Generation Sequencing, small molecule and RNA screening methods, all available through BMBF funding within the first funding period, translational cancer research will be facilitated by providing specimens with linked molecular and clinical data.
Projects- Identifizierung und Charakterisierung innovativer Biomarker einer individualisierten Osteosarkomtherapie (Dr. G. Richter, München)
- Metastasierung in Ewing Tumoren (Dr. G. Richter, München)
- Klonierung und Charakterisierung Ewing Tumor-spezifischer T-Zellrezeptoren (Dr. G. Richter, München)
- Evaluation von Apoptose-auslösenden Therapien beim Rhabdomyosarkom (Prof. S. Fulda, Frankfurt)
- SArkomREZidivRegister (Prof. J. Hartmann, Kiel)
- MRT-kontrollierter zielgerichteter Transport von gegen EWS/FLI1 gerichteter siRNA mittels anti-CD99 gekoppelter supramagnetischer Nanopartikel (Prof. U. Kontny, Freiburg)
- miRNA-Expression in Osteosarkomen und mesenchymalen Stammzellen (Prof. U. Dirksen, Münster)
- Epigenetische Regulation in Sarkomen und mesenchymalen Stammzellen (Prof. U. Dirksen, Münster)
- Genom-weites Screening in Ewing Sarkomen (Prof. U. Dirksen, Münster)
- Biomaterial Bank (Prof. U. Dirksen, Münster)
- Bioinformatik (Prof. U. Dirksen, Münster)
Prof. Dr. Heribert Jürgens
Universitätsklinikum Münster
Klinik und Poliklinik für Kinder- und Jugendmedizin
Pädiatrische Hämatologie und Onkologie
Albert-Schweitzer-Str. 33
48149 Münster
Phone: 0251 834 7742
Fax: 0251 834 7828
E-Mail: Heribert.Juergens@ukmuenster.de
Website: http://campus.uni-muenster.de/transarnet.html
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30. November 2015 (Transarnet)
Critical role of mitochondria-mediated apoptosis for JNJ-26481585-induced antitumor activity in rhabdomyosarcomaOncogene. 2015 Nov 30. doi: 10.1038/onc.2015.440. [Epub ahead of print]
Heinicke U, Kupka J, Fichter I, Fulda S
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25. November 2015 (Transarnet)
Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcomaOncotarget. 2015 Nov25
Hensel T, Giorgi C, Schmidt O., (…), Schäfer B, Burdach S, Richter GH.
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15. November 2015 (Transarnet)
Promises and challenges of Smac mimetics as cancer therapeuticsClin Cancer Res. 2015 Nov 15;21(22):5030-6. doi: 10.1158/1078-0432.CCR-15-0365.
Fulda S.
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1. November 2015 (Transarnet)
Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in Ewing sarcomaClin Cancer Res. 2015 Nov 1;21(21):4935-46.
Agelopoulos K, Richter GH, Schmidt E, Dirksen U, von Heyking K, Moser B, Klein HU,Kontny U, Dugas M, Poos K, Korsching E, Buch T, Weckesser M, Schulze I, Besoke R, Witten A, Stoll M, Köhler G, Hartmann W, Wardelmann E, Rossig C, Baumhoer D, Jürgens H, Burdach S, Berdel WE, Müller-Tidow C.
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22. September 2015 (Transarnet)
Local control in Ewing sarcoma of the chest wall: Results of the EURO-EWING 99 trialAnn Surg Oncol. 2015 Sep;22(9):2853-9
Bedetti B, Wiebe K, Ranft A, Aebert H, Schmidt J, Jürgens H, Dirksen U.
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3. June 2015 (Transarnet)
New small molecules targeting apoptosis and cell viability in osteosarcomaPLos One. 2015 Jun 3;10(6)
Maugg D, Rothenaigner I, Schorpp, Potukuchi HK, Korsching E, Baumhoer D, Hadian K, Smida J, Nathrath M.
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10. April 2015 (Transarnet)
TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndromeOncotarget. 2015 Apr 10;6(10):7727-40Ribi S, Baumhoer D, Lee K, Edison, Teo AS, Madan B, Zhang K, Kohlmann WK, Yao F, Lee WH, Hoi Q, Cai S, Woo XY, Tan P,Jundt G, Smida J, Nathrath M, Sung WK, Schiffman JD, Virshup DM, Hillmer AM. -
7. April 2015 (Transarnet)
Genomic heterogeneity of osteosarcoma – shift from single candidates to functional modulesPLoS One. 2015 Apr 7;10(4):e0123082. doi: 10.1371/journal.pone.0123082. eCollection 2015
Poos K, Smida J, Maugg D, Eckstein G, Baumhoer D, Nathrath M, Korsching E.
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1. April 2015 (Transarnet)
Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children’s Oncology GroupJ Pathol Clin Res. 2015 Apr;1(2):83-94.Volchenboum SL, Andrade J, Huang L, Barkauskas DA, Krailo M, Womer RB, Ranft A, Potratz J, Dirksen U, Triche TJ, Lawlor ER. -
1. April 2015 (Transarnet)
Targeting apoptosis for anticancer therapySemin Cancer Biol. 2015 Apr;31:84-8. doi: 10.1016/j.semcancer.2014.05.002. Epub 2014 May 22Fulda S. -
17. March 2015 (Transarnet)
Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell linesAnticancer Drugs. 2015 Mar;26(3):301-11. doi: 10.1097/CAD.0000000000000181Unland R, Borchardt C, Clemens D, Kool M, Dirksen U, Frühwald MC. -
17. March 2015 (Transarnet)
Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicingProc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1307-16. doi: 10.1073/pnas.1500536112. Epub 2015 Mar 3Selvanathan SP, Graham GT, Erkizan HV, Dirksen U, Natarajan TG, Dakic A, Yu S, Liu X, Paulsen MT, Ljungman ME, Wu CH, Lawlor ER, Üren A, Toretsky JA. -
1. March 2015 (Transarnet)
Smac mimetics as IAP antagonistsSemin Cell Dev Biol. 2015 Mar;39:132-8. doi: 10.1016/j.semcdb.2014.12.005. Epub 2014 Dec 27Fulda S. -
1. January 2015 (Transarnet)
Etoposide and carbo-or cisplatin combination therapy in refractory or relapsed Ewing sarcoma: a large retrospective studyPediatr Blood Cancer. 2015 Jan;62(1):40-4. doi: 10.1002/pbc.25230. Epub 2014 Sep 22van Maldegem AM, Benson C, Rutkowski P, Blay JY, van den Berg H, Placzke J, Rasper M, Judson I, Juergens H, Dirksen U, Gelderblom H. -
1. November 2014 (Transarnet)
Therapeutic exploitation of necroptosis for cancer therapySemin Cell Dev Biol. 2014 Nov;35:51-6. doi: 10.1016/j.semcdb.2014.07.002. Epub 2014 Jul 25
Fulda S.
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1. November 2014 (Transarnet)
Synthetic lethality by co-targeting mitochondrial apoptosis and PI3K/Akt/mTOR signalingMitochondrion. 2014 Nov;19 Pt A:85-7. doi: 10.1016/j.mito.2014.04.011. Epub 2014 Apr 26
Fulda S.
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28. August 2014 (Transarnet)
Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHACancer Lett. 2014 Aug 28;351(1):50-8. doi: 10.1016/j.canlet.2014.04.021. Epub 2014 May 6.Heinicke U, Fulda S. -
4. August 2014 (Transarnet)
A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated miceMol Cancer. 2014 Aug 4;13:182. doi: 10.1186/1476-4598-13-182Rosemann M, Gonzalez-Vasconcellos I, Domke T, Kuosaite V, Schneider R, Kremer M, Favor J, Nathrath M, Atkinson MJ. -
1. August 2014 (Transarnet)
Molecular pathways: targeting death receptors and smac mimeticsClin Cancer Res. 2014 Aug 1;20(15):3915-20. doi: 10.1158/1078-0432.CCR-13-2376. Epub 2014 May 13Fulda S. -
30. June 2014 (Transarnet)
Cyclophosphamide Compared With Ifosfamide in Consolidation Treatment of Standard-Risk Ewing Sarcoma: Results of the Randomized Noninferiority Euro-EWING99-R1 TrialJ Clin Oncol. 2014 Aug 10;32(23):2440-8. Epub 2014 Jun 30
Le Deley MC, Paulussen M, Lewis I, Brennan B, Ranft A, Whelan J, Le Teuff G, Michon J, Ladenstein R, Marec-Bérard P, van den Berg H, Hjorth L, Wheatley K, Judson I, Juergens H, Craft A, Oberlin O, Dirksen U.
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27. May 2014 (Transarnet)
Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation2014 May 27;2014. pii: bau042
Poos K, Smida J, Nathrath M, Maugg D, Baumhoer D, Neumann A, Korsching E. Database (Oxford)
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11. April 2014 (Transarnet)
The value of high-dose chemotherapy in patients with first relapsed Ewing sarcoma.Pediatr Blood Cancer. 2014 Apr 11. (Epub ahead of print).
Rasper M, Jabar S, Ranft A, Jürgens H, Amler S, Dirksen U. -
1. April 2014 (Transarnet)
Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma – reasons and consequencesGenes Cancer. 2014 Apr;5(1-2):56-63Arabi L, Gsponer JR, Smida J, Nathrath M, Perrina V, Jundt G, Ruiz C, Quagliata L, Baumhoer D. -
25. March 2014 (Transarnet)
Differentially expressed miRNAs in Ewing sarcoma compared to mesenchymal stem cells: Low miR-31 expression with effects on proliferation and invasion.PLoS One. 2014 Mar 25;9(3):e93067.
Karnuth B, Dedy N, Spiker T, (…), Dirksen U, Jürgens H, Bräuninger A. -
1. February 2014 (Transarnet)
Osteosarcomas of the jaws differ from their peripheral counterparts and require a distinct treatment approach. Experiences from the DOESAK Registry.Oral Oncol. 2014 Feb;50(2):147-53. Epub 2013 Nov 15.
Baumhoer D, Brunner P, Eppenberger-Castori S, Smida J, Nathrath M, Jundt G. -
15. January 2014 (Transarnet)
Molecular pathways: Targeting inhibitor of apoptosis proteins in cancer – from molecular mechanism to therapeutic applicationClin Cancer Res. 2014 Jan 15;20(2):289-95. Epub 2013 Nov 22.
Fulda S. -
1. January 2014 (Transarnet)
Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system.J Neurooncol. 2014 Jan;116(2):237-49. Epub 2013 Nov 22.
Unland R, Kerl K, Schlosser S, (…), Richter GH, (…), Frühwald MC. -
12. November 2013 (Transarnet)
Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment.Br J Cancer 2013 Nov 12;109(10):2523-32. Epub 2013 Oct 22.
Thiel U, Koscielniak E, Blaeschke F, (…), Lang P, Bader P, Burdach S. -
1. October 2013 (Transarnet)
Pelvic reconstruction with compound osteosynthesis following hemipelvectomy: A clinical study.Bone Joint J. 2013 Oct;95-B(10):1410-6.
Gebert C, Wessling M, Gosheger G, (…), Dirksen U, Hardes J. -
1. September 2013 (Transarnet)
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome in autophagosomal membranes.Cell Death Differ. 2013 Sep;20(9):1161-73.
Basit F, Christofanon S, Fulda S. -
1. September 2013 (Transarnet)
Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma.Cancer Lett. 2013 Sep 1;337(2):200-9.
Guenther MK, Graab U, Fulda S. -
1. September 2013 (Transarnet)
Renal Ewing tumors.Ann Oncol. 2013 Sep;24(9):2455-61. Epub 2013 Jun 11.
Zöllner S, Dirksen U, Jürgens H, Ranft A. -
23. August 2013 (Transarnet)
The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing’s sarcoma and promotes migration, invasion and cell growth.Biol Cell. 2013 Aug 23. (Epub ahead of print)
Grunewald TG, Willier S, Janik D, Unland R, (…) Dirksen U, Richter GH, (…), Burdach S, (…). -
1. August 2013 (Transarnet)
How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation.PLoS Comput Biol. 2013 Aug;9(8):e1003210. Epub 2013 Aug 29.
Poos K, Smida J, Nathrath M, Maugg D, Baumhoer D, Korsching E. -
6. May 2013 (Transarnet)
BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways.Oncogene. 2014 Mar 27;33(13):1713-24. Epub 2013 May 6.
Rapino F, Jung M, Fulda S. -
1. May 2013 (Transarnet)
G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcoma through PGF and MMP1.J Pathol. 2013 May;230(1):70-81. Epub 2013 Mar 14.
Richter GH, Fasan A, Hauer K, (…), Fulda S, (…), Burdach S.
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1. May 2013 (Transarnet)
Molecular targeted therapies for rhabdomyosarcoma: Focus on hedgehog and apoptosis signaling.Fulda S.
Klin Padiatr. 2013 May;225(3):115-119. Epub 2013 Apr 26.
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1. March 2013 (Transarnet)
First identification of Ewing’s sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.Miller IV, Raposo G, Welsch U, (…), Thiel U, (…), Richter GH, Burdach S, Grunewald T.
Biol. Cell. 2013 Mar 22:1-15.
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21. February 2013 (Transarnet)
Regulation of cell death in cancer – possible implications for immunotherapy.Front Oncol. 2013 Feb 21;3:29.
Fulda S. -
18. February 2013 (Transarnet)
Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies.PLoS One. 2013;8(2):e56408. Epub 2013 Feb 18.
Berger M, Dirksen U, Braeuninger A, Koehler G, Juergens H, Krumbholz M, Metzler M. -
14. February 2013 (Transarnet)
How to target apoptosis signaling pathways for the treatment of pediatric cancers.Front Oncol. 2013 Feb 14;3:22.
Fulda S. -
6. February 2013 (Transarnet)
Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists.Oncogene. 2014 Feb 6;33(6):671-6. Epub 2013 Mar 11.
Fulda S. -
21. January 2013 (Transarnet)
Alternative cell death pathways and cell metabolism.Int J Cell Biol. 2013;2013:463637. Epub 2013 Jan 21.
Fulda S. -
1. January 2013 (Transarnet)
Analyzing the basic principles of tissue microarray data measuring the cooperative phenomena of marker proteins in invasive breast cancer.Open Access Bioinformatics 2013:5 1-21
Buerger H, Boecker F, Packeisen J, Agelopoulos K, Poos K, Nadler W, Korsching E.
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30. November 2012 (Transarnet)
DKK2 mediates osteolysis, invasiveness and metastatic spread in Ewing Sarcoma.Cancer Res. 2012 Nov 30
Hauer K, Calzada-Wack J, Steiger K, (…), Baumhoer D, (…), Burdach S, Richter GH.
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9. November 2012 (Transarnet)
RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis.J Biol Chem. 2012 Nov 9;287(46):38767-77. Epub 2012 Aug 27.
Basit F, Humphreys R, Fulda S.
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3. October 2012 (Transarnet)
A novel role of IGF1 in Apo2L/TRAIL-mediated apoptosis of Ewing tumor cells.Sarcoma 2012:782970. Epub 2012 Oct 3.
van Valen F, Harrer H, Hotfilder M, Dirksen U, (…), Jürgens H.
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1. October 2012 (Transarnet)
Shifting the balance of mitochondrial apoptosis: Therapeutic perspectives.Front Oncol. 2012;2:121. Epub 2012 Oct 8.
Fulda S.
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1. October 2012 (Transarnet)
Is there ‘progression through grade’ in ductual invasive breast cancer?Breast Cancer Res Treat 2012 Oct;135(3):693-703.
Schymik B, Buerger H, Krämer A, (…), Korsching E.
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20. July 2012 (Transarnet)
Human leukocyte antigen distribution in German Caucasians with advanced Ewing’s sarcoma.Klin Padiatr. 2012 Oct;224(6):353-358. Epub 2012 Jul 20.
Thiel U, Wolf P, Wawer A, (…), Klingebiel T, Bader P, (…), Handgretinger R, Lang P, (…) Koscielniak E, (…), Richter GH, (…), Dirksen U, Jürgens H, (…), Burdach S.
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1. July 2012 (Transarnet)
Lissat A, Chao MM, Kontny U.ISRN Oncol. 2012;2012:609439. Epub May 28
Lissat A, Chao MM, Kontny U.
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1. May 2012 (Transarnet)
Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor binding sites in vivo.Schuch R, Agelopoulos K, Neumann A, Brandt B, Bürger H, Korsching E.
BMC Research Notes 2012 5:109 -
1. May 2012 (Transarnet)
MicroRNA profiling with correlation to gene expression revealed the oncogenic MiR-17-92 cluster to be up-regulated in osteosarcoma.Cancer Genet. 2012 May;205(5):212-9.
Baumhoer D, Zillmer S, Unger K, (…), Smida J, Nathrath M.
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9. April 2012 (Transarnet)
Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models.Rettinger E, Meyer V, Kreyenberg H, (…), Koscielniak E, Fulda S, (…), Klingebiel T, Bader P.
Front Oncol. 2012;2:32. Epub 2012 Apr 9 -
1. April 2012 (Transarnet)
Strong expression of CXCL12 is associated with favorable outcome in osteosarcoma.Mod Pathol. 2012 Apr:25(4):522-8. Epub 2011 Dec 16.
Baumhoer D, Smida J, Zillmer S, (…), Nathrath M.
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8. March 2012 (Transarnet)
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.Oncogene 2012 Mar 8;31(10):1287-1298
Mackintosh C, Ordonez JL, Garcia-Dominguez DJ, (…), Dirksen U, (…), de Alava E.
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8. February 2012 (Transarnet)
High STEAP1 expression is associated with improved outcome of Ewing’s sarcoma patients.Ann Oncol. 2012 Aug;23(8):2185-90. Epub 2012 Feb 8.
Grunewald T, Ranft A, Esposito I, (…), Baumhoer D, (…), Jürgens H, Dirksen U, Richter GHS, Burdach S.
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1. February 2012 (Transarnet)
High STEAP1 expression is associated with improved outcome of Ewing’s sarcoma patients.Grunewald T, Ranft A, Esposito I, (…), Baumhoer D, (…), Jürgens H, Dirksen U, Richter GHS, Burdach S.
Ann Oncol. 2012 Feb (epub ahead of print) -
1. December 2011 (Transarnet)
Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor binding sites in vivo.BMC Res Notes 2012 Feb 20;5:109
Schuch R, Agelopoulos K, Neumann A, Brandt B, Bürger H, Korsching E.
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11. November 2011 (Transarnet)
STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing Tumors.Grunewald T, Diebold I, Esposito I, (…), Thiel U, (…), Unland R, Müller-Tidow C, (…), Richter GHS, Burdach S. Mol Cancer Res. 2012 Jan;10(1):52-65. Epub 2011 Nov 11
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6. October 2011 (Transarnet)
The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells.Rettinger E, Kuci S, Naumann I, (…), Anzaghe M, (…), Klingebiel T, Fulda S, Bader P.
Cytotherapy. 2012 Jan;14(1):91-103. Epub 2011 Oct 6 -
26. September 2011 (Transarnet)
Grenzen von semantischen Technologien zur Realisierung einer interoperablen Wissensdatenbank.Roderfeld I, Bartholomäus S, Lablans M, Ückert F.
56. GMDS-Jahrestagung, 26.-29. September, Mainz 2011. GMS Publishing House; 2011. Doc11gmds503. Published: Sept 20, 2011 -
26. September 2011 (Transarnet)
Schemafreiheit und semantische Interoperabilität: Wege zu einer Metadatenarchitektur für die biomedizinische Forschung.Bartholomäus S, Lablans M, Roderfeld I, Ückert F. 56. GMDS-Jahrestagung, 26.-29. September, Mainz 2011.
GMS Publishing House; 2011. Doc11gmds436. Published: Sept 20, 2011 -
1. September 2011 (Transarnet)
The nature of the characteristic cementum-like matrix deposits in the wall of simple bone cysts.Histopathology. 2011 Sep:59(3):390-6
Baumhoer D, Smida J, Nathrath M, Jundt G.
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27. June 2011 (Transarnet)
Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancer.Hungermann D, Schmidt H, Natrajan R, Tidow N, Poos K, Reis-Filho J S, Brandt B, Bürger H, Korsching E. J Pathol. 2011 Aug;224(4):517-28. Epub 2011 Jun 27.
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25. June 2011 (Transarnet)
Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors.Lang P, Pfeiffer M, Teltschik HM, Schlegel P, Feuchtinger T, Ebinger M, Klingebiel T, Bader P, Schlegel PG, Beck J, Greil J, Handgretinger R. Best Pract Res Clin Haematol. 2011 Sep;24(3):403-11. Epub 2011 Jun 25
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25. June 2011 (Transarnet)
Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children.Schlegel P, Teltschik HM, Pfeiffer M, Handgretinger R, Schumm M, Koscielniak E, Feuchtinger T, Klingebiel T, Bader P, Schlegel PG, Greil J, Lang P. Best Pract Res Clin Haematol. 2011 Sep;24(3):443-52. Epub 2011 Jun 25
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1. June 2011 (Transarnet)
Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma.Hum Pathol. 2011 Jun;42(6):859-66. Epub 2011 Feb 2.
Baumhoer D, Smida J, (…), Bielack S, Nathrath M.
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25. March 2011 (Transarnet)
Risk of recurrence and survival after relapse in patients with Ewing sarcoma.Stahl M, Ranft A, Paulussen M, Bölling T, Vieth V, Bielack S, Görtitz I, Braun-Munzinger G, Hardes J, Jürgens H, Dirksen U. Pediatr Blood Cancer. 2011 Oct;57(4):549-53. Epub 2011 Mar 25
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15. March 2011 (Transarnet)
Specific recognition and inhibition of Ewing tumour growth by antigen-specific allo-restricted cytotoxic T cells.Thiel U, Pirson S, Müller-Spahn C, (…), Burdach S, Richter GHS.
Br J Cancer. 2011 Mar 15;104(6):948-56 -
18. January 2011 (Transarnet)
No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients.Thiel U, Wawer A, Wolf P, (…), Klingebiel T, (…), Dirksen U, (…), Koscielniak E, (…), Jürgens H, (…), Burdach S; Solid Tumor Working Party (STWP) and the Pediatric Disease Working Party (PDWP) of the European Group for Blood and Marrow Transplantation (EBMT); Asia Pacific Blood and Marrow Transplantation (APBMT); Pediatric Registry for Stem Cell Transplantations (PRST); MetaEICESS Study Group Ann Oncol. 2011 Jul;22(7):1614-21. Epub 2011 Jan 18
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1. January 2011 (Transarnet)
Providing trust and interoperability to federate distributed biobanks.Lablans M, Bartholomäus S, Ückert F. Stud Health Technol Inform. 2011;169:213-7
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1. September 2010 (Transarnet)
Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation.Haematologica. 2010 Sep;95(9):1579-86. doi: 10.3324/haematol.2009.019885. Epub 2010 Apr 7.
Selim Kuci, Bernhard Voss, Eva Rettinger, Gerrit Weber, Miriam Stais, Hermann Kreyenberg, Andre Willasch, Zyrafete Kuci, Ewa Koscielniak,
Stephan Klöss, Dorothee von Laer, Thomas Klingebiel, and Peter Bader. -
15. August 2010 (Transarnet)
Genomic Alterations and Allelic Imbalances are Strong Prognostic Predictors in Osteosarcoma.Clin Cancer Res. 2010 Aug 15;16(16):4256-67. Epub 2010 Jul 7
Smida J, Baumhoer D, Rosemann M, Walch A, Bielack S, Poremba C, Remberger K, Korsching E, Scheurlen W, Dierkes C, Burdach S, Jundt G, Atkinson MJ, Nathrath M.
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1. August 2010 (Transarnet)
Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children.Haematologica. 2010 Aug;95(8):1381-8. Epub 2010 Feb 9.
Pfeiffer MM, Feuchtinger T, Teltschik HM, Schumm M, Müller, I, Handgretinger R, Lang P.
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16. July 2010 (Transarnet)
BMC Cancer. 2010 Jul 16;10:372. doi: 10.1186/1471-2407-10-372.BMC Cancer. 2010 Jul 16;10:372. doi: 10.1186/1471-2407-10-372.
Helen J Knowles, Karl-Ludwig Schäfer, Uta Dirksen, Nicholas A Athanasou.
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1. July 2010 (Transarnet)
Approaching Ewing sarcoma.Future Oncol. 2010 Jul;6(7):1155-62
Dirksen U, Jürgens H.
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20. April 2010 (Transarnet)
Impact of EWS-ETS fusion type on disease progression in Ewing’s sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative EURO-E.W.N.G. 99 trial.J Clin Oncol. 2010 Apr 20;28(12): 1982-8. Epub 2010 Mar 22
Le Deley MC, Delattre O, Schaefer KL, Burchill SA, Koehler G, Hogendoorn PC, Lion T, Poremba C, Marandet J, Ballet S, Pierron G, Brownhill SC, Nesslböck M, Ranft A, Dirksen U, Oberlin O, Lewis IJ, Craft AW, Jürgens H, Kovar H.
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1. March 2010 (Transarnet)
Total body MRI-governed involved compartment irradiation combined with high-dose chemotherapy and stem cell rescue improves long-term survival in Ewing tumor patients with multiple primary bone metastases.Bone Marrow Transplant. 2010 Mar;45(3):483-9. doi: 10.1038/bmt.2009.184. Epub 2009 Aug 17.
S Burdach, U Thiel, M Schöniger, R Haase, A Wawer, M Nathrath, H Kabisch, C Urban, HJ Laws, U Dirksen, M Steinborn, J Dunst and H Jürgens.
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15. January 2010 (Transarnet)
The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES).Cancer. 2010 Jan 15;116(2):443-50. doi: 10.1002/cncr.24740.
Haeusler J, Ranft A, Boelling T, Gosheger G, Braun-Munzinger G, Vieth V, Burdach S, van den Berg H, Juergens H, Dirksen U.
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1. September 2009 (Transarnet)
WT1 peptide-specific T cells generated from peripheral blood of healthy donors: possible implications for adoptive immunotherapy after allogeneic stem cell transplantation.Leukemia. 2009 Sep;23(9):1634-42. doi: 10.1038/leu.2009.70. Epub 2009 Apr 9.
G Weber, J Karbach, S Kuci, H Kreyenberg, A Willasch, E Koscielniak, T Tonn, T Klingebiel, WS Wels, E Jaeger and P Bader.
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1. September 2009 (Transarnet)
CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression.Scand J Immunol. 2009 Sep;70(3):206-15.
Richter, GHS, Mollweide, M, Hanewinkel, K, Zobywalski, C, Burdach, S.
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1. July 2009 (Transarnet)
Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2.Cell Cycle. 2009 Jul 1;8(13):1991-6. Epub 2009 Jul 5.
Burdach S, Plehm S, Unland R, Dirksen U, Borkhardt A, Staege MS, Müller-Tidow C, Richter GH.
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31. March 2009 (Transarnet)
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation.Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5324-9. Epub 2009 Mar 16.
Richter GH, Plehm S, Fasan A, Rössler S, Unland R, Bennani-Baiti IM, Hotfilder M, Löwel D, von Luettichau I, Mossbrugger I, Quintanilla-Martinez L, Kovar H, Staege MS, Müller-Tidow C, Burdach S.