Research for Rare - Research for rare diseases

German multi-organ Auto-Immunity Network (GAIN)

Multi-organ autoimmune diseases belong to the “ultra-rare” disorders and have only recently been recognized being caused by monogenetic mutations in immune-regulatory genes. Patients are typically characterized by multi-organ inflammation including, but not limited to the bone marrow, gut, lungs, kidneys, skin, and the central nervous system (CNS). Genes recently added to the list include CTLA4, LRBA, NFκB1, NFκB2, STAT3, and LAT. This cohort of patients provides a frontier in medicine, as these rare monogenetic disorders are highly instructive for understanding and treating also more prevalent polygenic autoimmune disorders.


Prof. Dr. Bodo Grimbacher
University of Freiburg
Center for Chronic Immunodefiency (CCI), Medical Center
Breisacher Str. 115
79106 Freiburg i. Br.
Tel. +49 761 27077-732